Nova’s chemical metrology products leverage titration, a quantitative analysis method for measuring the concentration of components in liquids.

Dating as far back as 1750, titration has been improved constantly, making it a well-established technique and one of the most popular methods worldwide today. Modern titration techniques are fully automated and use high-precision dispensing devices, sensitive probes, and intelligent algorithms for analysis execution and evaluation.

The titration process requires a defined chemical reaction, a sensor that monitors the reaction, and stable titration reagents (titrants). A delivery of a well-defined, accurate volume of the sample containing the component to be measured, the analyte, is initially placed in a vessel equipped with a stirrer and the sensor. The titrants are dispensed stepwise while being constantly stirred. The signal from the sensor is continuously recorded to determine the end of the chemical reaction, known as the equivalence point or endpoint. The volume and concentration of the titrant required for reaching the endpoint is then used to calculate the component concentration.

Highlights and Benefits

  • Absolute method requiring no calibration
  • Extremely accurate and linear analytical technique
  • Multiple variation options given large array of available chemical reactions
  • High adaptability based on varied concentrations of titrant, sample volume, and dosing parameters
  • Wide range of possible Maintenance-free sensors (pH, redox, ion-selective, color, etc.)
  • High-precision dispensing device to ensure excellent accuracy and repeatability